Your Skin & Aging: FAQs, Hormones, and a Smarter Skincare Approach

August 1, 2025

As we age, changes in our skin can feel sudden and confusing—thinner texture, more dryness, loss of elasticity, and that “tired” look that shows up even after a good night’s sleep. These are natural changes, but they don’t have to be inevitable. In this post, we’re addressing some of the most common questions we get about aging skin, the role of estrogen, and how we integrate evidence-based solutions—like topical hormones and therapeutic skincare—to help restore skin vitality from the inside out.


Why does skin change so much with age?

Collagen loss starts in our 30s and accelerates during menopause, driven largely by hormonal shifts—especially the decline in estrogen. Estrogen supports hydration, elasticity, and collagen production, so when it drops, the skin becomes drier, thinner, and more fragile. You may also notice increased sensitivity, slower healing, and a duller appearance.


What role does estrogen play in skin health?

Estrogen isn’t just a reproductive hormone—it plays a critical role in skin physiology. It improves:


  • Collagen production

  • Skin thickness

  • Moisture retention

  • Wound healing

  • Sebum (natural oil) production

For some women, topical estrogen can be a safe, localized way to target skin aging—especially in areas like the face, neck, and even vaginal tissue, where estrogen receptors are abundant. We often use compounded low-dose topical estriol or estradiol as part of a customized plan. It’s not about reversing the clock—it’s about optimizing how your skin functions now.


Are topical hormones safe?

When prescribed appropriately and monitored, topical estrogen for skin use is generally well-tolerated and low-risk. Unlike systemic hormone therapy, these formulations are localized and often used at low doses. We assess your history and current hormone levels before initiating any protocol and monitor your response over time.


What else helps aging skin?

This is where skincare gets smarter. We look at:


  • Barrier repair: A compromised skin barrier leads to sensitivity, dryness, and inflammation.

  • Inflammation control: Chronic low-level inflammation accelerates aging.

  • Antioxidant support: To neutralize daily oxidative damage.

This is why we’re now offering Epionce® in our practice. It’s a dermatologist-developed line that aligns well with a functional approach—focused on skin barrier health, calming inflammation, and restoring a more resilient skin environment. We love it because it’s evidence-based, botanical-forward, and works beautifully alongside hormonal support or other medical treatments.


Where do I start if I’m noticing aging changes?

Start with a comprehensive evaluation: hormones, nutrition, stress, and skin history all matter. For some, that means testing estrogen levels and considering topical support. For others, it means addressing gut health, reducing inflammatory load, or rethinking skincare ingredients.


We’re here to help you understand what’s changing—and offer personalized tools to help your skin reflect how good you’re starting to feel inside.


Aging skin is not just a cosmetic issue—it’s a reflection of internal changes, especially hormone shifts. With thoughtful, integrative care—including hormone support when appropriate and smart topical therapies like Epionce—we can help restore balance and vitality at the cellular level.


*AI Disclosure: This content may contain sections generated with AI with the purpose of providing you with condensed helpful and relevant content, however all personal opinions are 100% human made as well as the blog post structure, outline and key takeaways.

* Affiliate Disclosure: Some of the links on www.elle-md.com may contain affiliate links meaning that we will get a commission for recommending products at no extra cost to you.

*Blog Disclaimer: Please note that reading our blog does not replace any health or medical advice consultation. Read our blog disclaimer here.

Meet the Drs.

Dr. Hendriks and Dr. Castillo MacKenzie are board-certified physicians, female, specialized, with over 10 years of experience.


Elle MD started after practicing in a traditional primary care setting together for over a decade. We grew frustrated with the current healthcare model, which places no emphasis on addressing the root cause of chronic disease. A lot of times, conventional care doesn’t even promote overall wellness! 


We founded Elle MD in Royal Oak, MI, with a vision of providing this care in a compassionate and personalized way. 

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