Is the Age of Menopause Hereditary? Understanding the Genetic and Environmental Factors

Erin Hendriks • August 22, 2024

Have you been wondering if the age of menopause is hereditary? Let’s get to the bottom of menopause and how it works.

Menopause is a significant milestone in a woman’s life, marking the end of her reproductive years. While it is a natural biological process, the age at which menopause occurs can vary widely among women. 


A common question many women have is whether the age of menopause is hereditary. At Elle MD, we focus on understanding the various factors that influence menopause, including genetic, lifestyle, and environmental influences. Let’s explore the hereditary aspects of menopause age and how lifestyle choices can impact this natural transition.


Understanding Menopause

Menopause is defined as the point in a woman’s life when she has not had a menstrual period for 12 consecutive months. It signifies the end of ovarian function and the cessation of hormone production, particularly estrogen and progesterone. Most women experience menopause between the ages of 45 and 55, with the average age being around 51.


Key Stages of Menopause

1. Perimenopause

This transitional phase can begin several years before menopause. During perimenopause, women may experience irregular menstrual cycles and symptoms such as hot flashes, night sweats, and mood swings.


2. Menopause

This is the stage when menstruation stops completely. It is diagnosed after a woman has gone 12 months without a menstrual period.


3. Postmenopause 

The years following menopause are termed postmenopause. Many symptoms of menopause may subside, but the risk for certain health conditions, such as osteoporosis and heart disease, may increase due to the lower hormone levels.


Is the Age of Menopause Hereditary?

Research suggests that genetics can play a significant role in determining the age at which a woman experiences menopause. Studies have shown that if a woman’s mother experienced early menopause, she is more likely to experience early menopause as well. Similarly, late menopause in a mother may indicate a later onset for her daughter. So yes, menopause age can be hereditary.


Genetic Factors Influencing Menopause

1. Family History 

The age at which a woman’s mother or sister enters menopause can provide clues about her own menopausal timeline. Studies indicate a strong correlation between the hereditary menopausal age of mothers and their daughters.


2. Genetic Markers 

Research has identified specific genetic markers that may influence the timing of menopause. For instance, variations in certain genes associated with hormone regulation and ovarian function can impact when menopause occurs.


3. Ethnicity and Genetics 

Genetic factors related to ethnicity can also affect the hereditary age of menopause. Studies have shown that certain ethnic groups tend to experience menopause earlier or later than others, suggesting a genetic component linked to ancestry.


Lifestyle and Environmental Factors

While genetics play a crucial role, lifestyle and environmental factors can also significantly influence the age of menopause, hereditary or not. In some cases, these factors can overshadow genetic predispositions, leading to variations in menopausal timing.


1. Smoking

Smoking is one of the most well-documented factors that can lead to earlier menopause. Nicotine and other chemicals in cigarettes can affect estrogen production and hasten ovarian aging. Women who smoke may experience menopause one to two years earlier than non-smokers.


2. Body Weight and Nutrition

Body weight and nutrition play important roles in determining the age of menopause. Women with lower body mass indexes (BMIs) tend to experience menopause earlier. Adequate nutrition and a healthy weight are essential for hormonal balance and may influence menopausal timing.


3. Physical Activity

Regular physical activity is beneficial for overall health and can influence hormonal balance. While moderate exercise promotes health, excessive physical activity, particularly when combined with low body weight, may lead to earlier menopause.


4. Reproductive and Gynecological Factors

Certain reproductive and gynecological factors can impact the timing of menopause:


  • Pregnancy and Childbirth:
    Women who have never been pregnant may experience menopause slightly earlier.
  • Contraceptive Use: Long-term use of hormonal contraceptives can affect menstrual cycles and may influence the timing of menopause, though the exact impact is still being studied.

5. Environmental Toxins

Exposure to environmental toxins, such as pesticides and endocrine-disrupting chemicals, can affect hormonal health and potentially lead to earlier menopause. Reducing exposure to such toxins may help support hormonal balance.


6. Chronic Stress

Chronic stress can have a significant impact on hormonal health and may contribute to earlier menopause. Stress affects the hypothalamic-pituitary-adrenal (HPA) axis, which plays a role in regulating hormones. Managing stress through relaxation techniques, mindfulness, and lifestyle changes can support hormonal health.


Functional Medicine Approach at Elle MD

At Elle MD, we take a holistic and personalized approach to menopause. Understanding the interplay between genetic, lifestyle, and environmental factors allows us to provide individualized care and support for women transitioning through menopause.


Personalized Assessments

We conduct thorough assessments to understand each woman’s unique health profile, considering genetic factors, lifestyle habits, and environmental exposures. This comprehensive evaluation helps us develop personalized strategies for managing menopause.


Lifestyle and Nutritional Support

We emphasize the importance of a balanced diet, regular physical activity, and stress management in supporting hormonal health. Our team provides guidance on nutrition, exercise, and mindfulness practices tailored to each woman’s needs.


Holistic Interventions

Our functional medicine approach incorporates holistic interventions to support overall well-being during menopause. We explore options such as herbal remedies, supplements, and hormone therapy when appropriate, to alleviate menopausal symptoms and promote optimal health.


All-Around Care for All Women

The age of menopause is hereditary to an extent, but the fact of the matter is that menopause is highly complicated and unique to every woman. While genetics play a significant role in determining the age of menopause, lifestyle and environmental factors can also have a profound impact. 


That’s why you deserve to work with someone who prioritizes your unique health situation.


At Elle MD, we are committed to providing personalized care and support to help women navigate menopause with confidence and ease.
Both of our doctors are especially passionate about taking care of women in a health climate that does this poorly. 


If you have questions about the hereditary age of menopause or need guidance on managing menopausal symptoms, we invite you to
schedule a consultation with our team. Together, we can explore strategies to support your health and well-being during this important stage of life.


*AI Disclosure: This content may contain sections generated with AI with the purpose of providing you with condensed helpful and relevant content, however all personal opinions are 100% human made as well as the blog post structure, outline and key takeaways.

* Affiliate Disclosure: Some of the links on www.elle-md.com may contain affiliate links meaning that we will get a commission for recommending products at no extra cost to you.

*Blog Disclaimer: Please note that reading our blog does not replace any health or medical advice consultation. Read our blog disclaimer here.

Meet the Drs.

Dr. Hendriks and Dr. Castillo MacKenzie are board-certified physicians, female, specialized, with over 10 years of experience.


Elle MD started after practicing in a traditional primary care setting together for over a decade. We grew frustrated with the current healthcare model, which places no emphasis on addressing the root cause of chronic disease. A lot of times, conventional care doesn’t even promote overall wellness! 


We founded Elle MD in Royal Oak, MI, with a vision of providing this care in a compassionate and personalized way. 

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A follow-up analysis of 71 participants found additional benefits: Lower BMI Reduced fasting glucose Decreased triglycerides Lower total and LDL cholesterol Reduced C-reactive protein (a marker of inflammation) Higher blood levels of trimethylamine N-oxide (TMAO) have been linked to increased cardiometabolic disease risk. A study in healthy volunteers found that the fasting mimicking diet cut TMAO levels by about 50%, reduced IGF-1, and improved insulin sensitivity. Bottom line: Even in generally healthy adults, periodic FMD cycles appear to improve several markers of metabolic and cardiovascular health. Effects in Type 2 Diabetes Some of the most promising findings come from people with type 2 diabetes. A recent 12-month randomized controlled trial in primary care found that monthly 5-day FMD cycles: Reduced the need for glucose-lowering medications Improved HbA1c Enhanced glycemic control in over half of the participants—compared to only 8% in the control group This is early but encouraging: the fasting mimicking diet may support better glycemic control while reducing medication burden—when used under medical supervision. Autophagy & Cellular Health Another exciting area of FMD research involves cellular cleanup and repair. A pilot randomized trial found that FMD increased autophagic flux—your body’s ability to recycle damaged cellular components. Participants also showed: Lower fasting glucose Higher ketone levels Reduced HOMA-IR (a calculated score used to estimate insulin resistance) Both low- and high-protein versions of FMD triggered autophagy at a molecular level, though the low-protein version led to higher ketone production. 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Body Composition & Metabolic Preservation Compared to traditional calorie restriction, FMD has some advantages: Better preservation of lean mass Less reduction in basal metabolic rate Similar weight loss results without slowing metabolism A high-protein version of FMD has also been explored, showing selective reductions in visceral fat, improvements in heart rate variability, and increased microbiome diversity. Takeaway The fasting mimicking diet is one of the most intriguing and well-researched nutrition interventions in the longevity space. Early data support benefits in metabolic health, cardiovascular markers, type 2 diabetes, cellular repair, and even cognitive performance. But like all emerging therapies, it requires more rigorous long-term study. If you’re considering FMD, especially if you have chronic medical conditions or take prescription medications, it’s essential to do so under the guidance of a clinician trained in metabolic and nutritional interventions. If you’re considering trying the fasting mimicking diet yourself, you can order the ProLon FMD kit here: ORDER: The Fasting-Mimicking Diet References: Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017 Feb 15;9(377):eaai8700. doi: 10.1126/scitranslmed.aai8700. PMID: 28202779; PMCID: PMC6816332. Videja M, Sevostjanovs E, Upmale-Engela S, Liepinsh E, Konrade I, Dambrova M. Fasting-Mimicking Diet Reduces Trimethylamine N-Oxide Levels and Improves Serum Biochemical Parameters in Healthy Volunteers. Nutrients. 2022 Mar 5;14(5):1093. doi: 10.3390/nu14051093. PMID: 35268068; PMCID: PMC8912301. Van den Burg EL, Schoonakker MP, van Peet PG, van den Akker-van Marle EM, Lamb HJ, Longo VD, Numans ME, Pijl H. Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial. Diabetologia. 2024 Jul;67(7):1245-1259. doi: 10.1007/s00125-024-06137-0. Epub 2024 Mar 28. PMID: 38546821; PMCID: PMC11153305. Espinoza SE, Park S, Connolly G, Qi W, Zhang N, Semwal M, Li Y, Lauzon M, Salmon AB, Hsu W, Wei M, Musi N. Effect of fasting-mimicking diet on markers of autophagy and metabolic health in human subjects. Geroscience. 2025 Dec 11. doi: 10.1007/s11357-025-02035-4. Epub ahead of print. PMID: 41372565. Burns L, Cooper S, Sarmad S, Funke G, Di Mauro A, Gaitanos GC, Tsintzas K. Effects of fasting-mimicking diets with low and high protein content on cardiometabolic health and autophagy: A randomized, parallel group study. Clin Nutr. 2025 Sep;52:299-312. doi: 10.1016/j.clnu.2025.08.004. Epub 2025 Aug 6. PMID: 40816210. Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. Epub 2015 Jun 18. PMID: 26094889; PMCID: PMC4509734. Wang Q, Xu J, Luo M, Jiang Y, Gu Y, Wang Q, He J, Sun Y, Lin Y, Feng L, Chen S, Hou T. Fasting mimicking diet extends lifespan and improves intestinal and cognitive health. Food Funct. 2024 Apr 22;15(8):4503-4514. doi: 10.1039/d4fo00483c. PMID: 38567489. Sadeghian M, Hosseini SA, Zare Javid A, Ahmadi Angali K, Mashkournia A. Effect of Fasting-Mimicking Diet or Continuous Energy Restriction on Weight Loss, Body Composition, and Appetite-Regulating Hormones Among Metabolically Healthy Women with Obesity: a Randomized Controlled, Parallel Trial. Obes Surg. 2021 May;31(5):2030-2039. doi: 10.1007/s11695-020-05202-y. Epub 2021 Jan 9. PMID: 33420673. Burns L, Cooper S, Sarmad S, Funke G, Di Mauro A, Gaitanos GC, Tsintzas K. Effects of fasting-mimicking diets with low and high protein content on cardiometabolic health and autophagy: A randomized, parallel group study. Clin Nutr. 2025 Sep;52:299-312. doi: 10.1016/j.clnu.2025.08.004. Epub 2025 Aug 6. PMID: 40816210.
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