15 Clear Signs of an Unhealthy Gut from a Trusted Functional Medicine and Hormone Doctor

Erin Hendriks • September 6, 2025

What does an unhealthy gut look like?


If you’ve been feeling off lately:like your body’s misfiring and nothing seems to work the way it used to:you’re not alone. For many women in their 40s and 50s, gut symptoms creep in quietly, then start to take over: digestion goes haywire, moods swing like a pendulum, and energy becomes a distant memory.


And the kicker? Most women don’t realize their gut health might be the root cause.

That’s where functional medicine comes in. At Elle MD, we help women unravel the connection between hormonal shifts and gut dysfunction:so you can finally feel like yourself again.


In case you’re new here, we are Dr. Hendriks and Dr. Castillo MacKenzie, and we help women in perimenopause and menopause restore balance, energy, and confidence through personalized, holistic care. If your gut and hormones feel out of sync, you’re in the right place. Learn more about our gut health services for women in Michigan.

Common Signs of Bad Gut Health

Bloating, gas, constipation, or diarrhea

Disruption in the gut microbiome can lead to poor digestion and uncomfortable symptoms like gas, bloating, irregularity, or frequent diarrhea.


IBS (Irritable Bowel Syndrome)

If you're constantly managing unpredictable digestion, cramping, or alternating constipation and diarrhea, it may point to IBS:a sign of deeper gut imbalance.


Acid reflux or heartburn

These aren’t just about stomach acid. They often stem from poor gut function or imbalanced bacteria, especially when chronic.


Persistent fatigue and poor sleep

An unhealthy gut can interfere with nutrient absorption and cortisol regulation, leaving you wired at night and exhausted by day.


Brain fog and trouble focusing

The gut-brain connection is real. Inflammation and imbalance in your gut can impair cognitive clarity, leading to mental fatigue. (Harvard Health on gut-brain connection)


Skin flare-ups (like eczema, acne, or rosacea)

Skin is a reflection of internal health. Gut dysfunction can trigger or worsen chronic skin conditions.


Mood swings, anxiety, or depression

Your gut produces neurotransmitters like serotonin. When it’s out of balance, your mood often is too.


Sugar cravings and poor appetite control

Bad bacteria feed on sugar and send signals to your brain that increase cravings, making it harder to eat balanced meals.


New or worsening food sensitivities

If you’re suddenly reacting to foods you used to tolerate, your gut lining may be compromised:known as “leaky gut.”


Unexplained weight gain or weight loss

Gut health impacts metabolism and hormone regulation. Shifts in weight with no clear cause may be microbiome-related.


Bad breath despite good hygiene

Persistent bad breath can stem from imbalances in your digestive tract or low stomach acid.


Frequent colds or infections (weakened immunity)

Your gut houses over 70% of your immune system. A disrupted microbiome can leave you more vulnerable to illness. (Cleveland Clinic on gut microbiome)


Frequent headaches or migraines

Inflammation and food sensitivities originating in the gut are common triggers for chronic headaches.


Joint pain or stiffness

Gut issues can increase systemic inflammation, which often manifests as joint discomfort.


Changes in body odor

If your body odor has changed or intensified despite good hygiene, your detox pathways:including your gut:may be overloaded.

Healthy Gut vs. Unhealthy Gut: What’s the Difference?

Your Gut as Your Second Brain


There’s a reason the gut is often called your "second brain." It houses trillions of bacteria that influence everything from digestion and metabolism to hormone production and mood.


When your gut is functioning well, it helps regulate estrogen, cortisol, thyroid function, and even neurotransmitters like serotonin. But when your gut is off? Hormones go haywire, and so does everything else.


A Healthy Gut Feels Like…

  • Comfortable digestion (no bloat, no pain)
  • Clear, radiant skin
  • Stable energy throughout the day
  • Strong immunity
  • Steady moods and clear thinking


An Unhealthy Gut Feels Like…

  • Constant discomfort or irregular digestion
  • Breakouts or skin inflammation
  • Fatigue that won’t go away
  • Getting sick often
  • Mood swings, irritability, or mental fog


What Causes an Unhealthy Gut?

Stress and Hormonal Imbalances

Women in perimenopause and menopause are especially vulnerable to gut issues due to fluctuating cortisol, estrogen, and progesterone levels. Chronic stress also weakens the gut lining and disrupts healthy bacteria.


Antibiotics, Medications & OTC Fixes

While sometimes necessary, antibiotics and over-the-counter medications can wipe out good bacteria, leading to long-term imbalances.


Processed Foods, Sugar, and Alcohol

These disrupt the microbiome, feed harmful bacteria, and create inflammation throughout the gut lining.


Poor Sleep and Sedentary Lifestyle

Lack of movement and restorative sleep impair gut motility and microbial diversity, compounding hormonal symptoms.


Lack of Microbial Diversity

Too much of one strain, not enough of another. A diverse microbiome is essential for resilience and hormonal balance.

Is Your Gut Trying to Get Your Attention? When to See a Functional Medicine Doctor


If you’ve cleaned up your diet and tried probiotics but still feel off, it may be time for deeper investigation. Persistent symptoms like fatigue, bloat, brain fog, or food sensitivities could indicate:

  • Hormone-gut dysfunction
  • Poor detoxification
  • Chronic inflammation


At Elle MD, we go beyond symptom-masking with comprehensive lab testing to uncover root causes. Learn more about how our gut health and functional medicine approach delivers personalized care.

How to Heal an Unhealthy Gut (Without Guesswork)



Start with Food:But Not Just Any Food


Support gut repair with anti-inflammatory, nutrient-dense foods:

  • Fiber-rich veggies
  • Fermented foods like kimchi and sauerkraut
  • Bone broth
  • Clean protein sources
  • Hydration and mineral balance


What Is the #1 Food for Gut Health?


Fiber. Specifically, prebiotic-rich fiber found in foods like garlic, leeks, asparagus, and onions. These feed your healthy gut bacteria and promote a balanced microbiome.

Signs your gut is healing


One of the most encouraging parts of gut healing is noticing the subtle (and sometimes not-so-subtle) signs that things are improving. Physically, you may experience more regular and comfortable bowel movements, less bloating or acid reflux, and even clearer, more radiant skin. Many women also notice more consistent energy levels throughout the day and better, more restful sleep.

But gut healing isn’t just physical—it’s emotional and mental too. A balanced microbiome supports better mood regulation, so you might feel more emotionally steady, less anxious, and better able to focus. That mental fog you’ve been fighting? It starts to lift.

Healing your gut is rarely linear. But when you give your body the right tools and support, the changes are real and long-lasting—and absolutely worth the journey.

The Takeaway: Don’t Ignore the Gut-Hormone Connection


If your digestion feels off, your energy is tanking, and your mood is swinging wildly, your gut might be crying out for help. And for women in the thick of hormonal chaos, it’s not just a gut issue:it’s a full-body signal.


Don’t keep guessing. At Elle MD, we take the confusion out of healing and deliver care that’s as unique as you are.

Explore our Michigan gut health services and take the first step toward restoring balance.


Let’s create a care plan that actually works:one that supports your gut, balances your hormones, and gets you back to living fully. Book a consultation with Elle MD today and say goodbye to the guesswork for good.

*AI Disclosure: This content may contain sections generated with AI with the purpose of providing you with condensed helpful and relevant content, however all personal opinions are 100% human made as well as the blog post structure, outline and key takeaways.

* Affiliate Disclosure: Some of the links on www.elle-md.com may contain affiliate links meaning that we will get a commission for recommending products at no extra cost to you.

*Blog Disclaimer: Please note that reading our blog does not replace any health or medical advice consultation. Read our blog disclaimer here.

Meet the Drs.

Dr. Hendriks and Dr. Castillo MacKenzie are board-certified physicians, female, specialized, with over 10 years of experience.


Elle MD started after practicing in a traditional primary care setting together for over a decade. We grew frustrated with the current healthcare model, which places no emphasis on addressing the root cause of chronic disease. A lot of times, conventional care doesn’t even promote overall wellness! 


We founded Elle MD in Royal Oak, MI, with a vision of providing this care in a compassionate and personalized way. 

WEIGHT MANAGEMENT FUNCTIONAL MEDICINE BOOK AN APPOINTMENT

Download your free guide

FREE GUIDE
By Dr. Erin Hendriks December 13, 2025
The fasting mimicking diet has gained momentum for its potential to improve metabolic health, support healthy aging, and even influence cellular regeneration. While human studies are still relatively small and short-term, the data so far is compelling. Here’s what the research says—and what it doesn’t—about this periodic 5-day, low-calorie, plant-forward diet. Metabolic & Cardiovascular Benefits One of the most well-studied areas of the fasting mimicking diet (FMD) is metabolic health. In a randomized trial of 100 healthy adults, three monthly cycles of a 5-day FMD led to: Decreased body weight Lower trunk and total body fat Reduced blood pressure Reduced IGF-1 (a hormone associated with aging and cancer risk) Participants at higher baseline risk saw even stronger improvements. A follow-up analysis of 71 participants found additional benefits: Lower BMI Reduced fasting glucose Decreased triglycerides Lower total and LDL cholesterol Reduced C-reactive protein (a marker of inflammation) Higher blood levels of trimethylamine N-oxide (TMAO) have been linked to increased cardiometabolic disease risk. A study in healthy volunteers found that the fasting mimicking diet cut TMAO levels by about 50%, reduced IGF-1, and improved insulin sensitivity. Bottom line: Even in generally healthy adults, periodic FMD cycles appear to improve several markers of metabolic and cardiovascular health. Effects in Type 2 Diabetes Some of the most promising findings come from people with type 2 diabetes. A recent 12-month randomized controlled trial in primary care found that monthly 5-day FMD cycles: Reduced the need for glucose-lowering medications Improved HbA1c Enhanced glycemic control in over half of the participants—compared to only 8% in the control group This is early but encouraging: the fasting mimicking diet may support better glycemic control while reducing medication burden—when used under medical supervision. Autophagy & Cellular Health Another exciting area of FMD research involves cellular cleanup and repair. A pilot randomized trial found that FMD increased autophagic flux—your body’s ability to recycle damaged cellular components. Participants also showed: Lower fasting glucose Higher ketone levels Reduced HOMA-IR (a calculated score used to estimate insulin resistance) Both low- and high-protein versions of FMD triggered autophagy at a molecular level, though the low-protein version led to higher ketone production. This suggests FMD may help activate longevity-linked pathways involved in cellular renewal. Longevity & Cognitive Effects Long-term animal studies point toward broader systemic benefits. In mice, repeated FMD cycles: Extended lifespan Reduced cancer incidence Promoted hippocampal neurogenesis (hello, brain health) Improved cognitive performance Enhanced stem cell regeneration across multiple organ systems A 2024 study in aging mice showed that FMD also improved gut health, boosted beneficial species like Lactobacillus johnsonii, reduced anxiety behaviors, and supported cognitive function. While animal data doesn’t automatically translate to humans, it provides a strong scientific rationale for ongoing human trials. Body Composition & Metabolic Preservation Compared to traditional calorie restriction, FMD has some advantages: Better preservation of lean mass Less reduction in basal metabolic rate Similar weight loss results without slowing metabolism A high-protein version of FMD has also been explored, showing selective reductions in visceral fat, improvements in heart rate variability, and increased microbiome diversity. Takeaway The fasting mimicking diet is one of the most intriguing and well-researched nutrition interventions in the longevity space. Early data support benefits in metabolic health, cardiovascular markers, type 2 diabetes, cellular repair, and even cognitive performance. But like all emerging therapies, it requires more rigorous long-term study. If you’re considering FMD, especially if you have chronic medical conditions or take prescription medications, it’s essential to do so under the guidance of a clinician trained in metabolic and nutritional interventions. If you’re considering trying the fasting mimicking diet yourself, you can order the ProLon FMD kit here: ORDER: The Fasting-Mimicking Diet References: Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017 Feb 15;9(377):eaai8700. doi: 10.1126/scitranslmed.aai8700. PMID: 28202779; PMCID: PMC6816332. Videja M, Sevostjanovs E, Upmale-Engela S, Liepinsh E, Konrade I, Dambrova M. Fasting-Mimicking Diet Reduces Trimethylamine N-Oxide Levels and Improves Serum Biochemical Parameters in Healthy Volunteers. Nutrients. 2022 Mar 5;14(5):1093. doi: 10.3390/nu14051093. PMID: 35268068; PMCID: PMC8912301. Van den Burg EL, Schoonakker MP, van Peet PG, van den Akker-van Marle EM, Lamb HJ, Longo VD, Numans ME, Pijl H. Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial. Diabetologia. 2024 Jul;67(7):1245-1259. doi: 10.1007/s00125-024-06137-0. Epub 2024 Mar 28. PMID: 38546821; PMCID: PMC11153305. Espinoza SE, Park S, Connolly G, Qi W, Zhang N, Semwal M, Li Y, Lauzon M, Salmon AB, Hsu W, Wei M, Musi N. Effect of fasting-mimicking diet on markers of autophagy and metabolic health in human subjects. Geroscience. 2025 Dec 11. doi: 10.1007/s11357-025-02035-4. Epub ahead of print. PMID: 41372565. Burns L, Cooper S, Sarmad S, Funke G, Di Mauro A, Gaitanos GC, Tsintzas K. Effects of fasting-mimicking diets with low and high protein content on cardiometabolic health and autophagy: A randomized, parallel group study. Clin Nutr. 2025 Sep;52:299-312. doi: 10.1016/j.clnu.2025.08.004. Epub 2025 Aug 6. PMID: 40816210. Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. Epub 2015 Jun 18. PMID: 26094889; PMCID: PMC4509734. Wang Q, Xu J, Luo M, Jiang Y, Gu Y, Wang Q, He J, Sun Y, Lin Y, Feng L, Chen S, Hou T. Fasting mimicking diet extends lifespan and improves intestinal and cognitive health. Food Funct. 2024 Apr 22;15(8):4503-4514. doi: 10.1039/d4fo00483c. PMID: 38567489. Sadeghian M, Hosseini SA, Zare Javid A, Ahmadi Angali K, Mashkournia A. Effect of Fasting-Mimicking Diet or Continuous Energy Restriction on Weight Loss, Body Composition, and Appetite-Regulating Hormones Among Metabolically Healthy Women with Obesity: a Randomized Controlled, Parallel Trial. Obes Surg. 2021 May;31(5):2030-2039. doi: 10.1007/s11695-020-05202-y. Epub 2021 Jan 9. PMID: 33420673. Burns L, Cooper S, Sarmad S, Funke G, Di Mauro A, Gaitanos GC, Tsintzas K. Effects of fasting-mimicking diets with low and high protein content on cardiometabolic health and autophagy: A randomized, parallel group study. Clin Nutr. 2025 Sep;52:299-312. doi: 10.1016/j.clnu.2025.08.004. Epub 2025 Aug 6. PMID: 40816210.
By Erin Hendriks October 6, 2025
The best menopause weight loss starts with hormone balance and gut health—discover functional medicine–approved supplements that truly support your body.
By Erin Hendriks October 6, 2025
How to Stop Menopause Weight Gain: A Functional Medicine Guide to Getting Your Body Back
By Erin Hendriks October 3, 2025
Struggling with weight gain, fatigue, or mood swings in midlife? Discover the best menopause doctors in Michigan & how functional medicine gets results.
By Erin Hendriks October 3, 2025
Perimenopause can bring weight gain, mood changes, and exhaustion. Functional medicine uncovers root causes to help you feel like yourself again
By Erin Hendriks September 26, 2025
Discover the signs of hormonal imbalance in women and how it affects weight, energy, mood, and cravings—plus real solutions backed by functional medicine.
By Erin Hendriks September 26, 2025
Feeling off but your labs are “normal”? Discover what kind of doctor actually treats hormone imbalance and helps women lose weight and feel better.
By Erin Hendriks September 19, 2025
Wondering what doctor treats hypothyroidism? Learn the difference between endocrinologists, and functional medicine doctors, and when to seek root-cause care.
By Erin Hendriks September 19, 2025
Wondering how to check your thyroid? Learn how doctors test it, what symptoms to watch for, and how functional medicine digs deeper for lasting relief.
By Erin Hendriks September 12, 2025
Struggling with low energy, brain fog, or weight changes? Discover the best thyroid supplements for women, plus which ones to avoid according to a hormone expert.